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Article

Sex steroids during bone growth: a comparative study between mouse models for hypogonadal and senile osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Oct 2009

Ophoff J, Venken K, Callewaert F, Boonen S, Bouillon R, Vanderschueren D

Abstract excerpt

SUMMARY: In this study, the role of disturbed bone mineral acquisition during puberty in the pathogenesis of osteoporosis was studied. To this end, a mouse model for senile and hypogonadal osteoporosis was used. Longitudinal follow-up showed that bone fragility in both models results from deficient bone build-up during early puberty. INTRODUCTION: Male osteoporosis may result from impaired bone growth. This study...

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Identifiers

PMID: 19238307
DOI: 10.1007/s00198-009-0851-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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