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Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system.

Biosensors & bioelectronics - 15 Mar 2004

Storhoff James J, Marla Sudhakar S, Bao Paul, Hagenow Susan, Mehta Hitesh, Lucas Adam, Garimella Viswanadham, Patno Tim, Buckingham Wes, Cork William, Müller Uwe R

Abstract excerpt

The development of a nanoparticle-based detection methodology for sensitive and specific DNA-based diagnostic applications is described. The technology utilizes gold nanoparticles derivatized with thiol modified oligonucleotides that are designed to bind complementary DNA targets. A glass surface with arrays of immobilized oligonucleotide capture sequences is used to capture DNA targets, which are then detected...

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PMID: 15128107
DOI: 10.1016/j.bios.2003.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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