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Article

How can dendritic cells cause autoimmune disease?

Immunology today - 1 May 2000

Drakesmith H, Chain B, Beverley P

Abstract excerpt

Immune responses against foreign antigens are initiated and controlled by dendritic cells (DCs). Accumulating evidence suggests that autoimmunity, involving T cells directed against self, can also be primed by DCs. We propose that DCs could induce autoimmunity following their differentiation by certain cytokines, or because of intrinsic defects in genes controlling DC function. Both processes result in DCs that...

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PMID: 10782051
DOI: 10.1016/s0167-5699(00)01610-8

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