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Article

Genomic structure and functional characterization of the human ADAM10 promoter.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2005

Prinzen Claudia, Müller Ulrich, Endres Kristina, Fahrenholz Falk, Postina Rolf

Abstract excerpt

The ADAM10 gene encodes a membrane-bound disintegrin-metalloproteinase, which, after overexpression in an Alzheimer disease (AD) mouse model, prevents amyloid pathology and improves long-term potentiation and memory. Because enhancing ADAM10 expression appears to be a reasonable approach for treatment of AD, we functionally analyzed the ADAM10 gene. Both human and mouse ADAM10 genes comprise approximately 160...

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Identifiers

PMID: 15972296
DOI: 10.1096/fj.04-3619fje

Genes

ADAM10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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