Article
The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
Respiratory research - 19 Jun 2006
Schedel Michaela, Depner Martin, Schoen Carola, Weiland Stephan K, Vogelberg Christian, Niggemann Bodo, Lau Susanne, Illig Thomas, Klopp Norman, Wahn Ulrich, von Mutius Erika, Nickel Renate, Kabesch Michael
Abstract excerpt
BACKGROUND: ADAM33, the first asthma candidate gene identified by positional cloning, may be associated with childhood asthma, lung function decline and bronchial hyperresponsiveness. However, replication results have been inconclusive in smaller previous study populations probably due to inconsistencies in asthma phenotypes or yet unknown environmental influences. Thus, we tried to further elucidate the role of...
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