Article
An unusual p53 mutation detected in Burkitt's lymphoma: 30 bp duplication.
Oncology reports - 1 Oct 2008
Smardova Jana, Grochova Diana, Fabian Pavel, Moulis Mojmir, Smarda Jan, Falkova Iva, Ravcukova Barbora, Vankova Jana, Vasova Ingrid
Abstract excerpt
Burkitt's lymphomas (BL) are aggressive rapidly growing tumors typified by a high c-myc expression resulting from t(8;14)(q24;q32), t(2;8)(p12;q24) or t(8;22)(q24;q11) translocations. Alterations of the p53 tumor suppressor are also relatively frequent in BL. Several approaches have been adopted for detection of the p53 aberrations such as immunohistochemical analyses, immunoblotting, DNA sequencing, fluorescence...
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