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Article

Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype.

The American journal of pathology - 1 Mar 2009

Boyle Joseph J, Harrington Heather A, Piper Emma, Elderfield Kay, Stark Jaroslav, Landis Robert C, Haskard Dorian O

Abstract excerpt

Intraplaque hemorrhage accelerates atherosclerosis via oxidant stress and contributes to lesion development and destabilization. Normally, macrophages scavenge hemoglobin-haptoglobin (HbHp) complexes via CD163, and this process provokes the secretion of the anti-inflammatory atheroprotective cytokine interleukin (IL)-10. We therefore tested the hypothesis that HbHp complexes may drive monocyte differentiation to...

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Share to Antigens, Differentiation, Myelomonocytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Confocal

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Source

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Identifiers

PMID: 19234137
DOI: 10.2353/ajpath.2009.080431
PMCID: PMC2665768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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