Article
Diversity of macrophage phenotypes and responses in atherosclerosis.
Cellular and molecular life sciences : CMLS - 1 May 2020
Jinnouchi Hiroyuki, Guo Liang, Sakamoto Atsushi, Torii Sho, Sato Yu, Cornelissen Anne, Kuntz Salome, Paek Ka Hyun, Fernandez Raquel, Fuller Daniela, Gadhoke Neel, Surve Dipti, Romero Maria, Kolodgie Frank D, Virmani Renu, Finn Aloke V
Abstract excerpt
The presence of macrophages within the plaque is a defining hallmark of atherosclerosis. Macrophages are exposed to various microenvironments such as oxidized lipids and cytokines which effect their phenotypic differentiation and activation. Classically, macrophages have been divided into two groups: M1 and M2 macrophages induced by T-helper 1 and T-helper 2 cytokines, respectively. However, for a decade, greater...
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