Article
TGFbeta affects collagen cross-linking independent of chondrocyte phenotype but strongly depending on physical environment.
Tissue engineering. Part A - 1 Jun 2008
Bastiaansen-Jenniskens Yvonne Maria, Koevoet Wendy, De Bart Anton C W, Zuurmond Anne-Marie, Bank Ruud A, Verhaar Jan A N, DeGroot Jeroen, van Osch Gerjo J V M
Abstract excerpt
Transforming growth factor beta (TGFbeta) is often used in cartilage tissue engineering to increase matrix formation by cells with various phenotypes. However, adverse effects of TGFbeta, such as extensive crosslinking in cultured fibroblasts, have also been reported. Our goal was to study effects of TGFbeta on collagen cross-linking and evaluating the role of cellular phenotype and physical environment. We...
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