Article

A Bio-inspired Latent TGF-β Conjugated Scaffold Improves Neocartilage Development

2025-02-08

Abstract excerpt

In cartilage tissue engineering, active TGF-β is conventionally supplemented in culture medium at highly supraphysiologic doses to accelerate neocartilage development. While this approach enhances cartilage extracellular matrix (ECM) biosynthesis, it further promotes tissue features detrimental to hyaline cartilage function, including the induction of tissue swelling, hyperplasia, hypertrophy, and ECM heterogeneit...

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Literature Corpus work: 9675c80a-8bc4-5709-a9cb-25e7c53fc34d
DOI: 10.1101/2025.02.03.636279

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