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Article

Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells.

Circulation research - 10 Apr 2009

Frontini Matthew J, O'Neil Caroline, Sawyez Cynthia, Chan Bosco M C, Huff Murray W, Pickering J Geoffrey

Abstract excerpt

A vital role of vascular smooth muscle cells (SMCs) is to stabilize the artery wall by elaborating fibrils of type I collagen. This is especially important in atherosclerotic lesions. However, SMCs in these lesions can be laden with lipids and the impact of this modification on collagen fibril formation is unknown. To address this, we converted human vascular SMCs to a foam cell state by incubating them with...

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Identifiers

PMID: 19229059
DOI: 10.1161/CIRCRESAHA.108.187302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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