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Article

The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.

Atherosclerosis - 1 Sept 2016

Dissmore Tixieanna, Seye Cheikh I, Medeiros Denis M, Weisman Gary A, Bradford Barry, Mamedova Laman

Abstract excerpt

BACKGROUND AND AIMS: The internalization of aggregated low-density lipoproteins (agLDL) mediated by low-density lipoprotein receptor related protein (LRP1) may involve the actin cytoskeleton in ways that differ from the endocytosis of soluble LDL by the LDL receptor (LDLR). This study aims to define novel mechanisms of agLDL uptake through modulation of the actin cytoskeleton, to identify molecular targets...

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Topics

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Share to Aorta
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Foam Cells

Share to Lipoproteins, LDL

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Myocytes, Smooth Muscle

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 27522265
DOI: 10.1016/j.atherosclerosis.2016.07.927
PMCID: PMC5060008

Genes

LRP1
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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