Article
The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection.
The Biochemical journal - 13 May 2009
Burger-van Paassen Nanda, Vincent Audrey, Puiman Patrycja J, van der Sluis Maria, Bouma Janneke, Boehm Günther, van Goudoever Johannes B, van Seuningen Isabelle, Renes Ingrid B
Abstract excerpt
SCFAs (short-chain fatty acids), fermentation products of bacteria, influence epithelial-specific gene expression. We hypothesize that SCFAs affect goblet-cell-specific mucin MUC2 expression and thereby alter epithelial protection. In the present study, our aim was to investigate the mechanisms that regulate butyrate-mediated effects on MUC2 synthesis. Human goblet cell-like LS174T cells were treated with SCFAs,...
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