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Article

Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.

Biochemical and biophysical research communications - 16 May 2008

van der Sluis Maria, Vincent Audrey, Bouma Janneke, Korteland-Van Male Anita, van Goudoever Johannes B, Renes Ingrid B, Van Seuningen Isabelle

Abstract excerpt

The mucin Muc2 is the main component of the intestinal mucus layer and thus plays important roles in intestinal protection. Therefore, it is important to understand its regulation during goblet cell differentiation. Foxa1 and Foxa2 forkhead box transcription factors (TFs) participate in transcriptional programs governing intestinal cell differentiation. Using immunohistochemistry, we showed a spatio-temporal...

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PMID: 18336786
DOI: 10.1016/j.bbrc.2008.02.158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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