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Article

Drug susceptibilities of yeast cells are affected when expressing mutant Candida albicans drug resistance protein.

International journal of antimicrobial agents - 1 Jul 2006

Gao Ping-Hui, Cao Yong-Bing, Jia Xin-Ming, Cao Ying-Ying, Quan Hua, Wang Yan, Jiang Yuan-Ying

Abstract excerpt

In the present study, wild-type and mutant Candida drug resistance protein 1 (Cdr1p) was expressed in Saccharomyces cerevisiae and phenotype alterations were observed in order to understand the importance of Cdr1p in azole resistance. Cdr1p was subjected to site-directed mutagenesis resulting in an alteration (W629L) to transmembrane segment 4 (TMS4). The susceptibilities to azole antifungal drugs of yeast cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16782311
DOI: 10.1016/j.ijantimicag.2006.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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