Article
Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Kasai Y, Nambu J R, Lieberman P M, Crews S T
Abstract excerpt
The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus...
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