Article
Practical and theoretical advances in predicting the function of a protein by its phylogenetic distribution.
Journal of the Royal Society, Interface - 6 Feb 2008
Kensche Philip R, van Noort Vera, Dutilh Bas E, Huynen Martijn A
Abstract excerpt
The gap between the amount of genome information released by genome sequencing projects and our knowledge about the proteins' functions is rapidly increasing. To fill this gap, various 'genomic-context' methods have been proposed that exploit sequenced genomes to predict the functions of the encoded proteins. One class of methods, phylogenetic profiling, predicts protein function by correlating the phylogenetic...
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