Article
Alignment and clustering of phylogenetic markers--implications for microbial diversity studies.
BMC bioinformatics - 24 Mar 2010
White James R, Navlakha Saket, Nagarajan Niranjan, Ghodsi Mohammad-Reza, Kingsford Carl, Pop Mihai
Abstract excerpt
BACKGROUND: Molecular studies of microbial diversity have provided many insights into the bacterial communities inhabiting the human body and the environment. A common first step in such studies is a survey of conserved marker genes (primarily 16S rRNA) to characterize the taxonomic composition and diversity of these communities. To date, however, there exists significant variability in analysis methods employed...
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