Article
Assigning functional linkages to proteins using phylogenetic profiles and continuous phenotypes.
Bioinformatics (Oxford, England) - 15 May 2008
Gonzalez Orland, Zimmer Ralf
Abstract excerpt
MOTIVATION: A class of non-homology-based methods for protein function prediction relies on the assumption that genes linked to a phenotypic trait are preferentially conserved among organisms that share the trait. These methods typically compare pairs of binary strings, where one string encodes the phylogenetic distribution of a trait and the other of a protein. In this work, we extended the approach to...
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