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Article

Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.

PloS one - 1 Jan 2009

Tang Sha, Le Phung Khanh, Tse Stephanie, Wallace Douglas C, Huang Taosheng

Abstract excerpt

Optic atrophy 1 (OPA1) is a dynamin-like GTPase located in the inner mitochondrial membrane and mutations in OPA1 are associated with autosomal dominant optic atrophy (DOA). OPA1 plays important roles in mitochondrial fusion, cristae remodeling and apoptosis. Our previous study showed that dOpa1 mutation caused elevated reactive oxygen species (ROS) production and resulted in damage and death of the cone and...

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Source

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Identifiers

PMID: 19221591
DOI: 10.1371/journal.pone.0004492
PMCID: PMC2637430

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.PMID 19221591Read ↗

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