Article

<i>Drosophila</i> model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

2023-03-20

Abstract excerpt

Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase ( OPA1 ) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner membrane. When associated with OPA1 mutations, DOA can present not only ocular symptoms but also multi-organ symptom...

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Literature Corpus work: 24f34ec9-f380-584b-abea-48970f714e9e
DOI: 10.1101/2023.03.17.533056

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