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Article

Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.

PloS one - 31 Aug 2009

Shahrestani Parvin, Leung Hung-Tat, Le Phung Khanh, Pak William L, Tse Stephanie, Ocorr Karen, Huang Taosheng

Abstract excerpt

Optic Atrophy 1 (OPA1) is a ubiquitously expressed dynamin-like GTPase in the inner mitochondrial membrane. It plays important roles in mitochondrial fusion, apoptosis, reactive oxygen species (ROS) and ATP production. Mutations of OPA1 result in autosomal dominant optic atrophy (DOA). The molecular mechanisms by which link OPA1 mutations and DOA are not fully understood. Recently, we created a Drosophila model...

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Identifiers

PMID: 19718456
DOI: 10.1371/journal.pone.0006867
PMCID: PMC2730818

Genes

OPA1
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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