Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.

PLoS genetics - 1 Jan 2008

Yarosh Will, Monserrate Jessica, Tong James Jiayuan, Tse Stephanie, Le Phung Khanh, Nguyen Kimberly, Brachmann Carrie B, Wallace Douglas C, Huang Taosheng

Abstract excerpt

Mutations in optic atrophy 1 (OPA1), a nuclear gene encoding a mitochondrial protein, is the most common cause for autosomal dominant optic atrophy (DOA). The condition is characterized by gradual loss of vision, color vision defects, and temporal optic pallor. To understand the molecular mechanism by which OPA1 mutations cause optic atrophy and to facilitate the development of an effective therapeutic agent for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Techniques

Share to GTP Phosphohydrolases

Share to Optic Atrophy, Autosomal Dominant

Share to Penetrance

Share to Superoxide Dismutase

Share to Vitamin E

Source

Open in PubMed Open full text

Identifiers

PMID: 18193945
DOI: 10.1371/journal.pgen.0040006
PMCID: PMC2174975

Genes

OPA1
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.PMID 18193945Read ↗

Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.Semantic proximity Read ↗

Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.Semantic proximity Read ↗

Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.Semantic proximity Read ↗

Tumor suppressor gene OSCP1/NOR1 regulates apoptosis, proliferation, differentiation, and ROS generation during eye development of Drosophila melanogaster.Semantic proximity Read ↗

Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency.Semantic proximity Read ↗

Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.Semantic proximity Read ↗

Targeting the OPA1 pathway in Autosomal Dominant Optic Atrophy (ADOA): 25 years from gene discovery to therapeutic strategy.Semantic proximity Read ↗

Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1Semantic proximity Read ↗

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.Semantic proximity Read ↗

OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.Semantic proximity Read ↗

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCsSemantic proximity Read ↗

<i>Drosophila</i> model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.