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Article

Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.

eLife - 23 Aug 2024

Nitta Yohei, Osaka Jiro, Maki Ryuto, Hakeda-Suzuki Satoko, Suzuki Emiko, Ueki Satoshi, Suzuki Takashi, Sugie Atsushi

Abstract excerpt

Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner membrane. When associated with OPA1 mutations, DOA can present not only ocular symptoms but also multi-organ symptoms...

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Identifiers

PMID: 39177028
DOI: 10.7554/eLife.87880
PMCID: PMC11343565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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