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Article

Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.

Biochemical and biophysical research communications - 27 Jul 2012

Huber-Keener Kathryn J, Evans Brad R, Ren Xingcong, Cheng Yan, Zhang Yi, Hait William N, Yang Jin-Ming

Abstract excerpt

Eukaryotic elongation factor-2 kinase (eEF-2K) is a Ca(2+)/calmodulin-dependent enzyme that negatively regulates protein synthesis. eEF-2K has been shown to be up-regulated in cancer, and to play an important role in cell survival through inhibition of protein synthesis. Post-translational modifi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

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Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 22749997
DOI: 10.1016/j.bbrc.2012.06.112
PMCID: PMC3614095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22749997-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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