Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.

doi:10.1073/pnas.1014720108

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Article

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2011

Melo Sonia, Villanueva Alberto, Moutinho Catia, Davalos Veronica, Spizzo Riccardo, Ivan Cristina, Rossi Simona, Setien Fernando, Casanovas Oriol, Simo-Riudalbas Laia, Carmona Javier, Carrere Jordi, Vidal August, Aytes Alvaro, Puertas Sara, Ropero Santiago, Kalluri Raghu, Croce Carlo M, Calin George A, Esteller Manel

Abstract excerpt

MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways. The disruption of miRNAs and their processing machineries also contributes to the development of human tumors. A common scenario for miRNA expression in carcinogenesis is emerging that shows that impaired miRNA production and/or down-regulation of these transcripts...

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Identifiers

PMID: 21368194
DOI: 10.1073/pnas.1014720108
PMCID: PMC3060242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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