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Association of high T allele frequency of CYP2B6 G516T polymorphism among ethnic south Indian HIV-infected patients with elevated plasma efavirenz and nevirapine

16 Feb 2009

Abstract excerpt

Sir, Plasma concentrations of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine are known to exhibit a high degree of inter-patient variability.1 A comprehensive analysis of the existing literature on the pharmacogenetic determinants of antiretroviral drug exposure, toxicity and activity has been undertaken.1 Plasma concentrations of efavirenz and nevirapine are known to be influenced...

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PMID: 19218571
DOI: 10.1093/jac/dkp033

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