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Article

Degradation of Saccharomyces cerevisiae transcription factor Gcn4 requires a C-terminal nuclear localization signal in the cyclin Pcl5.

Eukaryotic cell - 1 Apr 2009

Streckfuss-Bömeke Katrin, Schulze Florian, Herzog Britta, Scholz Eva, Braus Gerhard H

Abstract excerpt

Pcl5 is a Saccharomyces cerevisiae cyclin that directs the phosphorylation of the general amino acid control transcriptional activator Gcn4 by the cyclin-dependent kinase (CDK) Pho85. Phosphorylation of Gcn4 by Pho85/Pcl5 initiates its degradation via the ubiquitin/proteasome system and is regulated by the availability of amino acids. In this study, we show that Pcl5 is a nuclear protein and that artificial...

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Identifiers

PMID: 19218424
DOI: 10.1128/EC.00324-08
PMCID: PMC2669204

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Source receipt: pubmed, retrieved 7 Sept 2026.

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