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Article

Coevolution of cyclin Pcl5 and its substrate Gcn4.

Eukaryotic cell - 1 Feb 2005

Gildor Tsvia, Shemer Revital, Atir-Lande Avigail, Kornitzer Daniel

Abstract excerpt

Gcn4, a transcription factor that plays a key role in the response of Saccharomyces cerevisiae to amino acid starvation, is regulated at both the levels of translation and of protein stability. Regulated degradation of Gcn4 depends on its phosphorylation by the cyclin-dependent kinase Pho85, in conjunction with the cyclin Pcl5. The pathogenic yeast Candida albicans contains a functional homolog of Gcn4, which is...

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Identifiers

PMID: 15701793
DOI: 10.1128/EC.4.2.310-318.2005
PMCID: PMC549342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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