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Article

Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation.

Molecular and cellular biology - 1 Nov 2008

Aviram Sharon, Simon Einav, Gildor Tsvia, Glaser Fabian, Kornitzer Daniel

Abstract excerpt

Pho85 cyclins (Pcls), activators of the yeast cyclin-dependent kinase (CDK) Pho85, belong together with the p35 activator of mammalian CDK5 to a distinct structural cyclin class. Different Pcls target Pho85 to distinct substrates. Pcl5 targets Pho85 specifically to Gcn4, a yeast transcription factor involved in the response to amino acid starvation, eventually causing the degradation of Gcn4. Pcl5 is itself...

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Share to Amino Acids
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

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Source

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Identifiers

PMID: 18794371
DOI: 10.1128/MCB.00367-08
PMCID: PMC2573309

Genes

CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation.PMID 18794371Read ↗

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Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast.Semantic proximity Read ↗

Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.Semantic proximity Read ↗

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