Article
The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation.
Biochimica et biophysica acta - 1 May 2009
Grapp Marcel, Teichler Sabine, Kitz Julia, Dibaj Payam, Dickel Corinna, Knepel Willhart, Krätzner Ralph
Abstract excerpt
The transcription factor PAX6 plays an important role in transcriptional regulation of the peptide hormone glucagon from pancreatic alpha-cells. PAX6 contains two DNA binding domains, the paired domain (PD) and the homeodomain (HD). While the interaction of the PD with the PAX6 responsive elements G1 and G3 in the rat glucagon gene promoter is well understood, the role of the PAX6 HD for PAX6 binding and function...
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