Type I IFN response to Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) determines neuropathogenicity in mice.

doi:10.1016/j.virol.2009.01.001

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Article

Type I IFN response to Papiine herpesvirus 2 (Herpesvirus papio 2; HVP2) determines neuropathogenicity in mice.

Virology - 10 Apr 2009

Rogers K M, Deatheridge M, Breshears M A, Chapman S, Black D, Ritchey J W, Payton M, Eberle R

Abstract excerpt

Isolates of baboon alpha-herpesvirus Papiine herpesvirus 2 (HVP2) exhibit one of two distinct phenotypes in mice: extremely neurovirulent or apathogenic. Previous studies implicated the type I interferon (IFN) response as being a major factor in controlling infection by apathogenic isolates. To further investigate the possibility that the host IFN-beta response underlies the pathogenicity of the two HVP2...

Topics

Amino Acid Sequence
Animals
Cells, Cultured
Central Nervous System
Chlorocebus aethiops
Female
Herpes Simplex
Interferon-beta
Lethal Dose 50
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Knockout

Molecular Sequence Data

Mutation

Receptor, Interferon alpha-beta

Simplexvirus

Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 19215952
DOI: 10.1016/j.virol.2009.01.001
PMCID: PMC2729440

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