Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine.

PloS one - 17 Aug 2010

Halford William P, Püschel Ringo, Rakowski Brandon

Abstract excerpt

Herpes simplex virus 1 (HSV-1) ICP0(-) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44). If an ICP0(-) mutant of herpes simplex virus 2 (HSV-2) exhibited similar properties, such a virus might be used to vaccinate against genital herpes. The current study was initiated to explore this possibility. Several HSV-2 ICP0(-) mutant viruses were constructed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Safety
Share to Herpes Genitalis
Share to Herpesvirus 2, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunocompetence

Share to Interferon-beta

Share to STAT1 Transcription Factor

Share to Vaccines, Attenuated

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 20808928
DOI: 10.1371/journal.pone.0012251
PMCID: PMC2923193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine.PMID 20808928Read ↗

Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.Semantic proximity Read ↗

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit VaccineSemantic proximity Read ↗

Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.Semantic proximity Read ↗

Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.Semantic proximity Read ↗

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.Semantic proximity Read ↗

Immunization against genital herpes with a vaccine virus that has defects in productive and latent infectionSemantic proximity Read ↗

The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta.Semantic proximity Read ↗

Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.Semantic proximity Read ↗

Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.Semantic proximity Read ↗

The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma.Semantic proximity Read ↗

Neurovirulent factor ICP34.5 uniquely expressed in the herpes simplex virus type 1 Delta gamma 1 34.5 mutant 1716.Semantic proximity Read ↗

A herpes simplex virus type 1 ICP22 deletion mutant is altered for virulence and latency in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.