The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice.

doi:10.1007/BF01313767

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Article

The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice.

Archives of virology - 1 Jan 1993

Kurachi R, Daikoku T, Tsurumi T, Maeno K, Nishiyama Y, Kurata T

Abstract excerpt

We have investigated the pathogenicity of a US3 protein kinase-deficient mutant (L1 BR1) of herpes simplex virus type 2 (HSV-2) for 4-week-old ICR mice to define the role of the viral protein kinase in virus-host interaction. When mice were intraperitoneally infected with 10(5)PFU of L1 BR1, the virus disappeared from the peritoneal cavity by 2 days postinfection and failed to induce any significant...

Topics

Animals
Cells, Cultured
DNA Replication
DNA, Viral
DNA-Directed DNA Polymerase
Foot
Herpes Simplex
Herpesvirus 2, Human
Immunoblotting
Liver
Macrophages, Peritoneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Inbred ICR

Mutation

Protein Kinases

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 8257288
DOI: 10.1007/BF01313767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8257288-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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