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Article

The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.

Circulation research - 27 Mar 2009

You Bei, Jiang Yuan-Ying, Chen Shaoping, Yan Guijun, Sun Jianxin

Abstract excerpt

Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. Nur77 is highly expressed in vascular endothelial cells (ECs) and plays a role in the regulation of cell proliferation and angiogenesis; its role in vascular inflammation, however, remains unknown. Treatment of human umbilical vein ECs (HUVECs) with tumor...

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Source

Identifiers

PMID: 19213954
DOI: 10.1161/CIRCRESAHA.108.192286

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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