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Article

Hypocontractile airway smooth muscle phenotype exhibits enhanced β2 laminin chain expression in lung allergy model.

Molecular immunology - 1 Nov 2025

Pacheco-Alba Ivonne, Bazán-Perkins Blanca

Abstract excerpt

Sensitization with ovalbumin (OVA) in guinea pigs to induce anti-OVA IgE generates various allergic response phenotypes. One phenotype, characterized by the absence of bronchial obstruction and airway hyperresponsiveness in response to chronic antigen challenge, is termed non-responding (NR) and exhibits high IFN-γ levels. The Th1 cytokine profile is linked with high laminin β2 expression. This study evaluated...

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Asthma
Disease Models, Animal
Guinea Pigs
Laminin
Lung
Muscle, Smooth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40992104
DOI: 10.1016/j.molimm.2025.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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