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Article

Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008

Woodman Lucy, Siddiqui Salman, Cruse Glenn, Sutcliffe Amanda, Saunders Ruth, Kaur Davinder, Bradding Peter, Brightling Christopher

Abstract excerpt

Asthma is a major cause of morbidity and mortality worldwide. It is characterized by airway dysfunction and inflammation. A key determinant of the asthma phenotype is infiltration of airway smooth muscle bundles by activated mast cells. We hypothesized that interactions between these cells promotes airway smooth muscle differentiation into a more contractile phenotype. In vitro coculture of human airway smooth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18802103
DOI: 10.4049/jimmunol.181.7.5001
PMCID: PMC3992381

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