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Article

Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2007

Dekkers Bart G J, Schaafsma Dedmer, Nelemans S Adriaan, Zaagsma Johan, Meurs Herman

Abstract excerpt

Changes in the ECM and increased airway smooth muscle (ASM) mass are major contributors to airway remodeling in asthma and chronic obstructive pulmonary disease. It has recently been demonstrated that ECM proteins may differentially affect proliferation and expression of phenotypic markers of cultured ASM cells. In the present study, we investigated the functional relevance of ECM proteins in the modulation of...

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Identifiers

PMID: 17293376
DOI: 10.1152/ajplung.00331.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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