Article
Analysis of human papillomavirus type 16 E6 variants in relation to p53 codon 72 polymorphism genotypes in cervical carcinogenesis.
The Journal of general virology - 1 Feb 2000
van Duin M, Snijders P J, Vossen M T, Klaassen E, Voorhorst F, Verheijen R H, Helmerhorst T J, Meijer C J, Walboomers J M
Abstract excerpt
This study aimed to assess the role of specific human papillomavirus type 16 (HPV-16) variants, in combination with p53 codon 72 polymorphism genotypes, in cervical carcinogenesis. An initial sequence analysis of HPV-16 long control, E6 and E7 regions of 53 well-defined cervical samples containing HPV-16 revealed that a T to G transition at nucleotide position 350 within the E6 open reading frame was the most...
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