Article
p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx.
Cancer - 15 Jun 2007
Perrone Federica, Mariani Luigi, Pastore Elisa, Orsenigo Marta, Suardi Simona, Marcomini Barbara, DaRiva Luca, Licitra Lisa, Carbone Antonino, Pierotti Marco A, Pilotti Silvana
Abstract excerpt
BACKGROUND: Tobacco smoking, alcohol abuse, and high-risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect. METHODS: The aim of the study was to investigate the role of codon 72...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
