Article
Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas.
Cancer genetics and cytogenetics - 1 Apr 2004
Cortezzi Sylvia Sanches, Provazzi Paola Jocelan, Sobrinho João S, Mann-Prado José Carlos, Reis Patrícia Maria Pizzo, de Freitas Suzy Elaine Nobre, Filho José Francisco Góis, Fukuyama Erica E, Cordeiro José Antônio, Cury Patrícia Maluf, Maniglia José Vítor, Villa Luísa Lina, Tajara Eloiza Helena, Rahal Paula
Abstract excerpt
Head and neck squamous cell carcinoma is a disease associated with tobacco and alcohol abuse. There is evidence that the oncogenic human papillomavirus (HPV) may also be a risk for upper aerodigestive tract cancers. High-risk HPVs encode two early proteins, E6 and E7, that can bind to p53 and pRb...
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