Article
p53 Codon 72 polymorphism is linked to the development and not the progression of benign and malignant laryngeal tumours.
Oral oncology - 1 Oct 2001
Sourvinos G, Rizos E, Spandidos D A
Abstract excerpt
The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro. However, there are controversial results from several clinical studies in various human tumours. The purpose of our study was to investigate the significance of this p53 genotype with respect to the risk...
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