Article
Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease.
Alimentary pharmacology & therapeutics - 1 May 2009
Amre D K, Mack D R, Morgan K, Israel D, Lambrette P, Costea I, Krupoves A, Fegury H, Dong J, Grimard G, Deslandres C, Levy E, Seidman E G
Abstract excerpt
BACKGROUND: A recent genome-wide association study in adult patients with ulcerative colitis (UC) has implicated the interleukin 10 (IL-10) gene as an important candidate gene. Moreover, a UC-associated single nucleotide polymorphism (SNP) rs3024405 was also significantly associated with adult Crohn's disease (CD). AIMS: To examine whether IL-10-CD associations extended to paediatric-onset CD. METHODS: We...
Topics
- Adolescent
- Age of Onset
- Canada
- Case-Control Studies
- Child
- Child, Preschool
- Crohn Disease
- Female