Article
Interleukin-10 polymorphisms in Spanish patients with IBD.
Inflammatory bowel diseases - 1 Aug 2005
Fernandez Laura, Martinez Alfonso, Mendoza Juan L, Urcelay Elena, Fernandez-Arquero Miguel, Garcia-Paredes Julio, Diaz-Rubio Manuel, de la Concha Emilio G
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin-10 (IL-10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL-10 contains single nucleotide polymorphisms and 2 polymorphic microsatellites in the 5'-flanking region. Our...
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