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Article

DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease.

The American journal of gastroenterology - 1 Feb 2007

Biank Vincent, Friedrichs Frauke, Babusukumar Umesh, Wang Tao, Stoll Monika, Broeckel Ulrich, Kugathasan Subra

Abstract excerpt

OBJECTIVE: A significant association between the DLG5 variant (R30Q) and inflammatory bowel disease (IBD) has been confirmed in several independent adult IBD cohorts. There is growing evidence that gender significantly influences R30Q susceptibility in Crohn's disease (CD). Pediatric onset CD features a significantly lower incidence for female children compared with male children. We, therefore, studied the...

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Source

Identifiers

PMID: 17156146
DOI: 10.1111/j.1572-0241.2006.01011.x

Genes

DLG5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease.PMID 17156146Read ↗

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Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men.Semantic proximity Read ↗

Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.Semantic proximity Read ↗

Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant.Semantic proximity Read ↗

Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population.Semantic proximity Read ↗

Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children.Semantic proximity Read ↗

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