Article
The influence of apolipoprotein E genotype on visuospatial attention dissipates after age 80.
Neuropsychology - 1 Jan 2009
Negash Selam, Greenwood Pamela M, Sunderland Trey, Parasuraman Raja, Geda Yonas E, Knopman David S, Boeve Bradley F, Ivnik Robert J, Petersen Ronald C, Smith Glenn E
Abstract excerpt
Although it is established that apolipoprotein E (APOE) e4 allele increases the risk of Alzheimer's disease (AD), epidemiological studies indicate that genetic risk decreases late in life. This raises the question of whether the effects of APOE on cognition that are seen in midlife arise from a cognitive phenotype of APOE or from the presence of early AD in some APOE-e4 carriers. The authors addressed this...
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