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Article

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

Journal of medicinal chemistry - 12 Mar 2009

Kim Pilho, Zhang Liang, Manjunatha Ujjini H, Singh Ramandeep, Patel Sejal, Jiricek Jan, Keller Thomas H, Boshoff Helena I, Barry Clifton E, Dowd Cynthia S

Abstract excerpt

The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis (Mtb) while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb. We have synthesized analogues of both 4- and 5-nitroimidazoles and explored their antitubercular activities. The nitro group is required for both activities in all compounds. The key determinants of aerobic activity in the...

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Identifiers

PMID: 19209889
DOI: 10.1021/jm801246z
PMCID: PMC2765526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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