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Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

27 Dec 2014

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Zolpidem (Ambien, 1 ) is an imidazo[1,2- a ]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2- a ]pyridine-3-carboxyamides. Zolpidem was found to have antituberculosis activity (MIC...

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Share to Mycobacterium research and diagnosis
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PMID: 25984566
DOI: 10.1021/id500008t

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