Article
Influence of ABCB-1 C3435T polymorphisms on plasma nevirapine and efavirenz levels and their effects on virologic and immunological outcomes in HIV/TB co-infected Thai adults under anti-retroviral therapy.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 2012
Uttayamakul Sumonmal, Likanonsakul Sirirat, Manosuthi Weerawat, Wichukchinda Nuanjun, Shioda Tatsuo, Khusmith Srisin
Abstract excerpt
ATP-binding cassette, sub-family B (encoded by ABCB-1 or MDR-1) has an important role in cellular export of antiretroviral agents. A previous study showed that ABCB-1 C3435T polymorphism affects plasma efavirenz and nelfinavir concentrations and rate of CD4+ T cell recovery after starting antiretroviral treatment (ART). The present study examined the influence of ABCB-1 polymorphisms on plasma nevirapine and...
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