Article
ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.
Endocrine-related cancer - 1 Dec 2008
Pancholi Sunil, Lykkesfeldt Anne E, Hilmi Caroline, Banerjee Susana, Leary Alexandra, Drury Suzanne, Johnston Stephen, Dowsett Mitch, Martin Lesley-Ann
Abstract excerpt
Acquired resistance to endocrine therapies remains a major clinical obstacle in hormone-sensitive breast tumors. We used an MCF-7 breast tumor cell line (Tam(R)-1) resistant to tamoxifen to investigate this mechanism. We demonstrate that Tam(R)-1 express elevated levels of phosphorylated AKT and MAPK3/1-activated RPS6KA2 compared with the parental MCF-7 cell line (MCF-7). There was no change in the level of total...
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